Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity
نویسندگان
چکیده
منابع مشابه
ANTI-INFLAMMATORY AND ANTIPYRETIC ACTIVITY OF SELECTIVE COX-2 INHIBITOR WITH CONVENTIONAL NSAIDs
Objective: The selective COX-2 inhibitor has high cardiovascular side effects, with low GI side effects, as compare to the conventional NSAID and it is proved that low dose of any drugs is always good for the health due to chances of less adverse effects. So the main objective of this research work is to lower the dose of selective COX -2 inhibitor, combine with a conventional NSAID and find ou...
متن کاملSynthesis, Anti-Inflammatory and Anti- Nociceptive Activities and Cytotoxic Effect of Novel Thiazolidin-4-ones Derivatives as Selective Cyclooxygenase (COX-2) Inhibitors
Objective(s): Nowadays, COX- 2 inhibitors such as valdecoxib are removed from the market because of their cardiovascular toxicity and their potential to increase the risk of strokes. In response to this, medicinal chemists have attempted to synthesize new classes of COX-2 Inhibitors. Materials and Methods: In this study, three novel analogues of thiazolidin-4-ones derivatives ...
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Since, their introduction, COX (cyclooxygenase enzyme)-2 specific inhibitors have become a rapidly growing segment of the prescription drug market. Researchers have recently focused on the potentially lethal side effects associated with their. FDA has banned the use of nimesulide (hepatotoxic) in pediatric patients and rofecoxib (cardiovascular complications) in both adults and children. COX-2 ...
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In this study, effects of rofecoxib, celecoxib, nimesulide on the acute phase of inflammation were studied in the carrageenan-induced paw edema model and their influence on the chronic phase of inflammation was evaluated in the cotton pellet granuloma tests. Additionally, effects of these drugs on capillary vascular permeability were examined in the hyaluronidase test and were compared with tha...
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Epidemiological and experimental data support the use of nonsteroidal anti-inflammatory drugs, including specific inhibitors of cyclooxygenase 2 (Cox-2), as chemopreventive agents in a number of epithelial cancers, including colon, mammary, esophageal, lung, and oral cavity (1). There is also evidence to suggest that nonsteroidal anti-inflammatory drugs may be chemopreventive against ovarian ca...
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ژورنال
عنوان ژورنال: Life Sciences
سال: 2009
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2009.09.007